Disulfiram (sold under the trade names Antabuse and Antabus) is a drug used to support the treatment of chronic alcoholism by producing an acute sensitivity to ethanol (drinking alcohol). Disulfiram works by inhibiting the enzyme acetaldehyde dehydrogenase, which means that many of the effects of a "hangover" are felt immediately after alcohol is consumed. "Disulfiram plus alcohol, even small amounts, produce flushing, throbbing in head and neck, throbbing headache, respiratory difficulty, nausea, copious vomiting, sweating, thirst, chest pain, palpitation, dyspnea, hyperventilation, tachycardia, hypotension, syncope, marked uneasiness, weakness, vertigo, blurred vision, and confusion. In severe reactions there may be respiratory depression, cardiovascular collapse, arrhythmias, myocardial infarction, acute congestive heart failure, unconsciousness, convulsions, and death." In the body, alcohol is converted to acetaldehyde, which is then broken down by acetaldehyde dehydrogenase. If the dehydrogenase enzyme is inhibited, acetaldehyde builds up and causes unpleasant effects. Disulfiram should be used in conjunction with counseling and support. Disulfiram has been studied as a possible treatment for cancer Under normal metabolism, alcohol is broken down in the liver by the enzyme alcohol dehydrogenase to acetaldehyde, which is then converted by the enzyme acetaldehyde dehydrogenase to a harmless acetic acid derivative (acetyl coenzyme A). A drug sometimes used in the management of alcoholism, which causes severe nausea and vomiting, sweating, breathlessness, headache and chest pain if any alcohol is taken after it has been given. Disulfiram inhibits the enzyme aldehyde dehydrogenase that breaks down acetaldehyde, a toxic metabolite of alcohol, so that this accumulates. The method is a form of aversion therapy and is not without danger of collapse and death from the toxic effects. Azithromycin teva Zithromax for sinus infection Find patient medical information for Antabuse Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Looking for online definition of Antabuse in the Medical Dictionary? Antabuse explanation free. What is Antabuse? Meaning of Antabuse medical term. ANTABUSE. n. the trade name for the drug disulfiram. ANTABUSE "The person was prescribed Antabuse, which is also known as disulfiram. ". Disulfiram (tetraethylthiuramdisulfide) was accidentally discovered to combine with ethyl alcohol to produce a noxious effect by Jacobsen and Hald, in Denmark, in 1947. After its therapeutic introduction by Martensen-Larsen in 1948, this chemical compound, with the market name of Antabuse, has been used in the treatment of patients suffering from chronic alcoholism in unknown numbers of thousands. As with any new treatment method, an overly enthusiastic reception occurred, with successes reported in 60% to 80% of the patients so treated and followed for six months to a year. However, the enthusiasm has diminished, until now the recovery rates are about the same as those reported for other therapeutic modalities. Unfortunately, rather than helping those who did not benefit from other techniques, disulfiram works best with those patients who generally do better with any type of treatment. Unlike the other modal verbs, it is only found in the past tense. Therefore, when it is used with do to make negatives and questions, the form of the auxil... Definition of antabuse Antabuse Definition Of Respect BestPrices!, Antabuse definition of Antabuse by Medical dictionary Buy kamagra jelly bangkokAmoxicillin side Antabuse_Definition_Of_Autonomy best ED products - Generic Lev1tra, Tadalaf1l Cial1s, Vardenaf1l lev1tra with lowest price and high quality Antabuse_Definition_Of_AutonomySafeandSecure. What is ANTABUSE? definition of ANTABUSE Psychology.. StCanadianPharmacy Antabuse Definition Of Democracy.. Medical Definition of disulfiram. a compound C10H20N2S4 that causes a severe physiological reaction to alcohol and is used especially in the treatment of alcoholism — Disulfiram sold under the trade names Antabuse and Antabus is a drug used to support the treatment of chronic alcoholism by producing an acute sensitivity to ethanol drinking alcohol. Define Antabuse. Antabuse synonyms, Antabuse pronunciation, Antabuse translation, English dictionary definition of Antabuse. A trademark for the drug.