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Dr. Sharp and his staff strive to provide consistently exceptional results whether your treatment requires implants, complicated bridgework, treatment for gum disease, dentures or simply routine restorations. A 57-year-old woman with metastatic breast carcinoma treated by surgery and high-dosage tamoxifen chemotherapy developed tamoxifen retinopathy characterized by white superficial retractile retinal lesions primarily in the paramacular area. At postmortem examination, the retinal lesions seen clinically were identified as being 3 to 10 microns in diameter in the macular area, and 30 to 35 microns in diameter in the paramacular area. The lesions were confined to the nerve fiber layer and inner plexiform layer and stained positive with stains for glycosaminoglycans. Electron microscopic examination revealed that the smaller lesions were intracellular and the larger lesions extracellular. The lesions were composed of randomly oriented branching electron dense 6-nm filaments accompanied by occasional electron dense coated vesicles measuring 60 to 70 nm in diameter. The lesions appeared to be occurring in axons and seemed to represent products of axonal degeneration. Tamoxifen is used for hormone-dependent types of breast cancer. It works by blocking the effect of estrogen in the body and thus stopping the growth of cancer cells that possess the estrogen receptors. Since this medication reduces the effects of estrogen, side effects will resemble menopausal symptoms such as hot flashes, vaginal dryness and insomnia. Since then, I've experienced horrible hot flashes, insomnia, depression (worsened), big weight gain, just to name a few. I was told 6 months after chemo that the steroid they gave me had caused cataracts. two years ago noticed I was having severe problems driving at night due to blurring of vision. 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Watch for Ocular Effects of Breast Cancer Drugs - American Academy.. Tamoxifen Retinopathy Best Prices Excellent Quality. Tamoxifen retinopathy a rare but serious complication. - NCBI - NIH. A 57-year-old woman with metastatic breast carcinoma treated by surgery and high-dosage tamoxifen chemotherapy developed tamoxifen retinopathy characterized by white superficial retractile retinal lesions primarily in the paramacular area. Tamoxifen retinopathy. CRAIG A. MCKEOWN,1 MANO SWARTZ,' JOHANNES BLOM,2. AND JOHN M. MAGGIANO3. From the 'Ophthalmology Service and the. Tamoxifen Retinopathy Condition/keywords drug toxicity, toxic maculopathy Photographer Soon Tae Kim, Asan Medical Center Imaging device Optical coherence tomography system Zeiss cirrus HD-OCT 4000 Description OCT image of an 58-year-old woman with a bilateral tamoxifen maculopathy.