Metoprolol is a cardioselective β1-adrenergic blocking agent used for acute myocardial infarction (MI), heart failure, angina pectoris and mild to moderate hypertension. It may also be used for supraventricular and tachyarrhythmias and prophylaxis for migraine headaches. Metoprolol is structurally similar to bisoprolol, acebutolol and atenolol in that it has two substituents in the para position of the benzene ring. The β1-selectivity of these agents is thought to be due in part to the large substituents in the para position. At low doses, metoprolol selectively blocks cardiac β1-adrenergic receptors with little activity against β2-adrenergic receptors of the lungs and vascular smooth muscle. Unlike propranolol and pindolol, metoprolol does not exhibit membrane-stabilizing or intrinsic sympathomimetic activity. Membrane-stabilizing effects are only observed at doses much higher than those needed for β-adrenergic blocking activity. Metoprolol possesses a single chiral centre and is administered as a racemic mixture. Absorption: Well absorbed after oral administration. Distribution: Crosses the blood-brain barrier, crosses the placenta; small amounts enter breast milk. Metabolism and Excretion: Mostly metabolized by the liver (primarily by CYP2D6; the CYP2D6 enzyme system exhibits genetic polymorphism); ~7% of population may be poor metabolizers and may have significantly ↑ metoprolol concentrations and an ↑ risk of adverse effects. TIME/ACTION PROFILE (cardiovascular effects)When switching from immediate-release to extended-release product, the same total daily dose can be used PO: (Adults) Antihypertensive/antianginal– 25–100 mg/day as a single dose initially or 2 divided doses; may be ↑ q 7 days as needed up to 450 mg/day (immediate-release) or 400 mg/day (extended-release) (for angina, give in divided doses). MI– 25–50 mg (starting 15 min after last IV dose) q 6 hr for 48 hr, then 100 mg twice daily. Heart failure– 12.5–25 mg once daily (of extended-release), can be doubled every 2 wk up to 200 mg/day. Migraine prevention– 50–100 mg 2–4 times daily (unlabeled). IV: (Adults) MI– 5 mg q 2 min for 3 doses, followed by oral dosing. Tablets (tartrate): 25 mg, 50 mg, 100 mg Cost: Generic: All strengths $7.18/100Extended-release tablets (succinate; Toprol XL): 25 mg, 50 mg, 100 mg, 200 mg Cost: Generic: 25 mg $35.68/100, 50 mg $41.93/100, 100 mg $53.95/100, 200 mg $84.54/100Solution for injection: 1 mg/m LIn Combination with:hydrochlorothiazide (Dutoprol, Lopressor HCT). See combination drugs.metoprolol is a sample topic from the Davis's Drug Guide. Prednisone fast heart rate Where can i buy real clomid Feb 28, 2018. What is metoprolol? What are Metoprolol side effects? Who should avoid Metoprolol? Click here to learn more about this beta blocker. Metoprolol, marketed under the tradename Lopressor among others, is a medication of the. The MHRA granted the Intas Pharmaceuticals Limited Marketing Authorisation licences for metoprolol tartrate 50mg and 100mg tablets for. Dec 7, 2018. Metoprolol is used to treat angina chest pain and hypertension high blood pressure. Learn about side effects, interactions and indications. Metoprolol can help reduce your symptoms if you have too much thyroid hormone in your body (thyrotoxicosis). You'll usually take it together with medicines to treat an overactive thyroid. This medicine comes as tablets and is only available on prescription. It's also given by injection, but this is usually done in hospital. Your doctor may advise you to take your first dose before bedtime because it could make you feel dizzy. If you don't feel dizzy after the first dose, take metoprolol in the morning. If you have metoprolol more than once a day, try to space the doses evenly throughout the day. Metoprolol belongs to the class of medications called beta-blockers. Metoprolol is used to treat high blood pressure and prevent the symptoms of certain types of angina (chest pain). It is also used to help reduce the risk of death right after a heart attack. Metoprolol is also taken by people who have had a heart attack to reduce the risk of having another one. Metoprolol is often used in combination with other high blood pressure medications such as diuretics (water pills) when the use of one medication by itself is not enough to control blood pressure. This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here. 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