Azithromycin hplc

Discussion in 'Northwest Pharmacy Canada' started by Giz, 06-Sep-2019.

  1. cossackmsu Guest

    Azithromycin hplc


    Крахмал прежелатинизированный, гипролоза, коповидон, кросповидон, кальция гидрофосфат безводный, тальк, натрия лаурилсульфат, магния стеарат, гипромеллоза, макрогол 6000, титана диоксид, диметикон. Описание: овальные двояковыпуклые таблетки, покрытые пленочной оболочкой, белого цвета, с поперечной насечкой на одной стороне, разделяющей таблетку на две равные половины. На поперечном разрезе таблетки видно белое ядро и тонкое белое пленочное покрытие. антибиотик - азалид Код ATX: J01FA10 Фармакологическое действие Азитромицин - бактериостатический антибиотик широкого спектра действия из группы макролидов-азалидов. Механизм действия азитромицина связан с подавлением синтеза белка микробной клетки. Связываясь с 508-субъединицей рибосом, угнетает пептидтранслоказу на стадии трансляции и подавляет синтез белка, замедляя рост и размножение бактерий. В высоких концентрациях оказывает бактерицидное действие. Обладает активностью в отношении ряда грамположительных, грамотрицательных, анаэробов, внутриклеточных и других микроорганизмов. Микроорганизмы могут изначально быть устойчивыми к действию антибиотика или могут приобретать устойчивость к нему. A simple, precise and accurate reversed phase liquid chromatographic method has been developed for the assay of azithromycin in powder for oral suspension. The chromatographic separation was achieved on a Asahipak ODP 40 E(250 mm × 4.6 mm, 5 μm) analytical column. A mixture of methanol–ammonium dihydrogen phosphate (0.05M) (, v/v) (p H 9.0) was used as the mobile phase, at a flow rate of 1.5 m Lmin and detector wavelength at 210 nm. The retention time of azithromycin was found to be at 8.0 min. The validation of the proposed method was carried out for specificity, linearity, accuracy, precision, robustness and stability indicating assay. The linear dynamic range is from 382–1208 μgm L Azithromycin [9-de-oxy-9a-aza-9a-methyl-9a-homoerythromycin A dihydrate] is an azalide, a subclass of macrolide antibiotics as shown in Fig.1. It is derived from erythromycin; however it differs chemically from erythromycin in that a methyl substituted nitrogen atom is incorporated into the lactone ring, thus making the lactone ring 15 membered.

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    The present study was designed to develop a simple, validated liquid chromatographic method for the analysis of azithromycin in bulk and pharmaceutical. Azithromycin is used for worsening of bronchitis symptoms such as shortness of breath andAzithromycin is used to treat severe cases of thickened mucus caused by bacterial infections. Azithromycin is the first of a class of antibiotics designated chemically as azalides, a subclass of macrolides. Chemically it is derived by insertion of a nitrogen atom into the lactone ring of.

    Azithromycin is used to treat severe cases of thickened mucus caused by bacterial infections. Azithromycin is also used to treat severe cases of nasal congestion caused by sinusitis, to treat certain cases of pneumonia, to treat inflammation of the throat caused by bacterial infections, to treat certain bacterial skin infections, to treat inflammation of the urethra caused by bacterial infections, to treat inflammation of the cervix, to treat certain genital diseases in men, and to treat middle ear infections in children. Azithromycin should not be used to treat elderly patients, patients that require hospitalization, or patients who have severe health problems such as immunodeficiency. Azithromycin cannot be used to treat viral infections such as the common cold or flu. Azithromycin should also not be used to treat all bacterial infections as this may lead to the development of drug-resistant bacteria. It should only be used for the treatment of bacterial infections where it is effective. Azithromycin is a prescription medicine that belongs to a class of medicines called Macrolide Antibacterial. Macrolide antibacterials are a class of antibiotics that are used to treat certain kinds of bacterial infections. In this study, a high-performance liquid chromatographic method was developed for the quantitative determination of erythromycin (EM), roxithromycin (RXM), and azithromycin (AZM) in rat plasma with amperometric detection under a standardized common condition using clarithromycin (CAM) as an internal standard. This method was also proved to be applicable for the determination of CAM by employing RXM as an internal standard. Each drug was extracted from 150 μl of plasma sample spiked with internal standard under an alkaline condition with tert.-butyl methyl ether. The detector cell potential for the oxidation of the drugs was set at 950 m V. The linearity of the calibration curves were preserved over the concentration ranges of 0.1-10 μg/ml for EM and RXM, and 0.03-3.0 μg/ml for CAM and AZM. Coefficients of variation and relative error were less than 9% and ±7%, respectively. TY - JOURT1 - Determination of erythromycin, clarithromycin, roxithromycin, and azithromycin in plasma by high-performance liquid chromatography with amperometric detection AU - Taninaka, Chieko AU - Ohtani, Hisakazu AU - Hanada, Erika AU - Kotaki, Hajime AU - Sato, Hitoshi AU - Iga, Tatsuji PY - 2000/2/11Y1 - 2000/2/11N2 - In this study, a high-performance liquid chromatographic method was developed for the quantitative determination of erythromycin (EM), roxithromycin (RXM), and azithromycin (AZM) in rat plasma with amperometric detection under a standardized common condition using clarithromycin (CAM) as an internal standard. The analytical method presented here was proved to be useful for the investigation of the pharmacokinetic characteristics of EM, CAM, RXM, and AZM in rats. This method was also proved to be applicable for the determination of CAM by employing RXM as an internal standard.

    Azithromycin hplc

    Zithromax C38H72N2O12 - PubChem, Azithromycin - Uses, Side-effects, Reviews, and. -

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  4. LOINC. 2009361. Azithromycin - Dose. PROMPT. N. 2009360. Azithromycin - Time/Date, Last Dose. PROMPT. N. 2009362. Antimicrobial Level - Azithromycin S/P. Resultable. N.

    • Antimicrobial Level - Azithromycin by HPLC, Serum or.
    • PRODUCT INFORMATION.
    • Assay of Azithromycin by HPLC in tablet dosage form -.

    A simple liquid chromatographic method was developed for the estimation of azithromycin raw material and in pharmaceutical forms. The sample was chromatographed on a reverse phase C18. Азитромицин — антибиотик широкого спектра действия. Это средство является прекрасным и эффективным средством в отношении большинства патогенных микроорганизмов. In this study, a high-performance liquid chromatographic method was developed for the quantitative determination of erythromycin EM, roxithromycin RXM, and azithromycin AZM in rat plasma with.

     
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