MRI signal abnormalities in the disc have been described predominantly as low signal intensity on T2 weighted images. Loss of disc height and disc calcification are the most common spine imaging manifestations. Homogentisic acid and its metabolites are deposited in fibrous and connective tissues including the intervertebral disc leading to premature degeneration. D., Non ASSR Member Excerpta Extraordinaire Mentor Award: No Institution where work was conducted William Beaumont Hospital Affiliation and Department Diagnostic Radiology, William Beaumont Hospital 100 RO Address 3601 W. Royal Oak, Michigan 48073 Phone: 2488980648, Fax: 2488985490 Email: [email protected] Alkaptonuria (Ochronosis) is a rare metabolic disorder characterized by deficiency of homogentisic acid oxidase. Increased signal intensity on T1 weighted images in connective tissue elsewhere in the body has been described due to the paramagnetic effects of the deposited metabolites. 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