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    There was a good amount of new data released early last month at the Third Conference on Retroviruses and Opportunistic Infections in Washington, D. While it was unlikely that any OI news could compete successfully with the raucous choruses proclaiming protease inhibitors to be the HIV-infected world's salvation, long-awaited data was presented on two very large studies looking at various drugs in different regimens for the prevention of mycobacterium avium complex (MAC). Michael Marco was there and prepared this report ACTG 196, chaired by Chicago Rush Medical College's Connie Benson, was presented to a standing-room-only audience during Tuesday afternoon's MAC symposium. ACTG 196 (also known as CPCRA 009) was a phase III, prospective, randomized, double-blind study comparing clarithromycin (Biaxin) to rifabutin (Mycobutin) to the two drugs together for the prevention of MAC in HIV-infected individuals with CD4 cell counts less than 100. The genesis of this three-arm comparative trial grew out of the feeling of many clinicians that while rifabutin has been the standard-of-care for MAC prophylaxis, clarithromycin presented an excellent option. Both are now FDA-approved for the prophylaxis of M. Indeed, in the treatment of MAC infection, clarithromycin is generally recognized as the most effective (and necessary) agent in the antimycobacterial combination. Data from Abbott Labs which was presented at last autumn's ICAAC conference showed clarithromycin to be extremely effective: a 68% reduction in the risk of developing active MAC infection--and a survival benefit to boot--compared to placebo. Of those persons who "failed" (came down with active MAC or developed MAC bacteremia in their blood) on clarithromycin prophylaxis, however, a whopping 60% were found to have developed clarithromycin-resistant MAC. Azithromycin vs clarithromycin - MedHelp Clinical manifestation of macrolide antibiotic toxicity in. Azithromycin vs clarithromycin – Casa Marazzo
     
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