Clonidine

Discussion in 'Canada Drug' started by janno, 10-Sep-2019.

  1. poltora User

    Clonidine


    Clonidine (known by the trade names Catapres, Kapvay, Nexiclon, Clophelin, and others) is a depressant substance of the imidazoline class. It is primarily used to treat high blood pressure, but can also be used for a variety of conditions that include attention deficit hyperactivity disorder, anxiety disorders, tic disorders, substance withdrawal, migraine, diarrhea, and certain pain conditions. As the first anti-hypertensive agent with a clearly identifiable central site of action, clonidine has been an important pharmacological tool in discovering the role of central α-adrenoceptors in the physiology of central blood pressure regulation. It has been prescribed to treat psychiatric disorders including stress, sleep disorders, and hyperarousal caused by post-traumatic stress disorder, borderline personality disorder, and other anxiety disorders. In the early 1960s, the medicinal chemist Helmut Stähle was tasked by Boehringer Ingelheim with synthesizing a peripherally active a-adrenergic compound that would be useful for nasal decongestion as simple nose drops. A locally acting a-adrenergic vasoconstrictor agent was expected to provide relief from the symptoms of the common cold by shrinking the swollen nasal membranes and producing an unobstructed air passage. The synthetic design of clonidine was achieved when Stähle had the idea of substituting two chlorine groups on the phenyl group of the imidazoline structure, which most of the newer decongestive agents at the time were derived from. At that time, a double halogen substitution was still unusual for pharmaceuticals, and the prevailing opinion was that compounds with several halogen atoms would at best be useful as pesticides. Текст данной статьи практически полностью повторяет инструкцию по применению лекарственного средства, предоставляемую его производителем. Это нарушает правило о недопустимости инструкций в энциклопедических статьях. Кроме того, предоставленные данные могут быть недостаточно объективными и достоверными (особенно в части эффективности и безопасности препарата). Для соблюдения нейтральности изложения необходимо переработать данную статью, основываясь на независимых авторитетных источниках информации. Широко используется при лечении артериальной гипертензии. Синонимы: Гемитон, Катапресан, Хлофазолин, Atensina, Bapresan, Capresin, Catapres, Catapresan, Chlophazolin, Chlornidinum, Clonidini hydrochloridum, Clonidin hydrochlorid, Clonilon, Clonisin, Clonidine, Haemiton, Hemiton, Hyposyn, Ipotensinum, Namestin, Normopresan, Prescatan и др. -адренорецепторы сосудодвигательных центров, расположенных на дне ромбовидной ямки четвертого желудочка. Это уменьшает эфферентный поток симпатических импульсов из ЦНС и снижает высвобождение норадреналина из нервных окончаний, оказывая симпатолитическое действие.

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    Clonidin ist eine chemische Verbindung aus der Gruppe der Imidazoline. Es wird als Arzneistoff zur Behandlung der arteriellen Hypertonie Bluthochdruck. Clonidine, an imidazoline-derivative hypotensive agent is a centrally-acting α2- adrenergic agonist. It crosses the blood-brain barrier and acts in the. Catapres® clonidine hydrochloride, USP is a centrally acting alpha-agonist hypotensive agent available as tablets for oral administration in three dosage.

    It’s available as a patch, an oral tablet, and an oral extended-release tablet. Clonidine extended-release tablets are available as the brand-name drug Kapvay. Clonidine extended-release tablets are used to treat symptoms of attention deficit hyperactivity disorder (ADHD). This drug may be used as part of a combination therapy. In some cases, they may not be available in every strength or form as the brand. That means you may need to take it with other drugs. Clonidine belongs to a class of drugs called centrally acting alpha-agonists. It isn’t known exactly how clonidine extended-release tablets work to reduce symptoms of ADHD. We do know that clonidine works in the part of the brain that helps regulate behavior, attention, and how we express emotion. However, this effect might go away the longer you take it. Mild side effects may go away within a few days or a couple of weeks. Talk to your doctor or pharmacist if they’re more severe or don’t go away. Лактозы моногидрат, крахмал картофельный, магния стеарат Таблетки белого цвета, плоскоцилиндрической формы, с фаской Гипотензивные средства. Альфа 2 –адреномиметики центральные, производные имидазолина Код АТХ С02АС01. Фармакологические свойства Хорошо всасывается из желудочно-кишечного тракта независимо от приема пищи. Биодоступность при длительном применении – около 65 %. Максимальная концентрация в плазме достигается через 1,5-2,5 часа. Связывание с белками плазмы крови составляет 20-40 %. Метаболизируется в печени (около 50 % всосавшегося препарата). Период полувыведения – 12-16 часов, у пациентов с нарушениями функции почек увеличивается до 41 часа, что требует снижения дозы препарата.

    Clonidine

    Клонидин - инструкция по применению, дозы, побочные, Clonidine - DrugBank

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  5. Содержание. 1 История открытия. 2 Эффективность и механизм воздействия. 3 Показания, применение. 4 Дозировки. 5 Побочные действия. 6 Основные противопоказания.

    • Клонидин инструкция по применению, рекомендации.
    • Catapres Clonidine Side Effects, Interactions, Warning, Dosage..
    • Clonidine Reviews Everyday Health.

    Фармакологическое действие. Антигипертензивное средство центрального действия. Механизм действия обусловлен стимуляцией постсинаптических α2-адренорецепторов. Clonidine tablets Catapres are used alone or in combination with other medications to treat high blood pressure. Clonidine extended-release. Клонидин многим известен под названием клофелин. Знаменит он не только своими лечебными свойствами, но и случаями его использования в криминальной среде.

     
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